The multifunctional role of filaggrin in allergic skin disease

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:131

Article

McAleer, Maeve A.^1,2,3  Irvine, Alan D.^1,2,3 

[1] Our Ladys Childrens Hosp, Natl Childrens Res Ctr, Dublin 12, Ireland

[2] Our Ladys Childrens Hosp, Dept Paediat Dermatol, Dublin 12, Ireland

[3] Trinity Coll Dublin, Dept Clin Med, Dublin, Ireland

关键词: Filaggrin;    atopy;    dermatitis;    eczema;    IL-1 beta;    skin barrier;    transepidermal water loss;   

DOI  :  10.1016/j.jaci.2012.12.668

来源: Elsevier

【 摘 要 】

Filaggrin is a major structural protein in the stratum corneum of the epidermis. Mutations in the filaggrin gene are the most significant known genetic risk factor for the development of atopic dermatitis. Mutations in the human filaggrin gene (FLG) also confer risk for the associated allergic diseases of food allergy, asthma, and allergic rhinitis. These discoveries have highlighted the importance of skin barrier function in the pathogenesis of atopic diseases and have motivated a surge in research characterizing the filaggrin-deficient skin barrier and its consequences. In this review we discuss the mechanisms through which mutations in this protein contribute to the pathogenesis of atopic dermatitis and associated atopic conditions. We focus on recent human and murine discoveries characterizing the filaggrin-deficient epidermis with respect to biophysical, immunologic, and microbiome abnormalities. (J Allergy Clin Immunol 2013;131:280-91.)

【 授权许可】

Free