The-590C/T and-34C/T interleukin-4 promoter polymorphisms are not associated with atopic eczema in childhood

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:108

Article

Elliott, K ; Fitzpatrick, E ; Hill, D ; Brown, J ; Adams, S ; Chee, P ; Stewart, G ; Fulcher, D ; Tang, MM ; Kemp, A ; King, E ; Varigos, G ; Bahlo, M ; Forrest, S

关键词: atopy;    eczema;    dermatitis;    asthma;    genetic;    IL-4;    promoter;    polymorphism;    association;    linkage disequilibrium;   

DOI  :  10.1067/mai.2001.117180

来源: Elsevier

【 摘 要 】

Susceptibility to the development of asthma and other atopic diseases is known to have a genetic component. To date, several studies have linked chromosome 5q31 to asthma and atopy in human beings. This region harbors a cluster of cytokine and growth factor genes, IL-4 presenting as a prime atopy candidate gene, inasmuch as it plays a pivotal role in the atopy pathway. Our approach was to identify polymorphisms within the promoter regions of IL-4 and test their association with atopic eczema. Polymorphisms were typed in a cohort of 76 small nuclear families and 25 triads with childhood atopic eczema. The genotypes were used to test for linkage in the presence of association with atopic eczema. A new polymorphism, -34C/T, was identified and studied with a known polymorphism, -590C/T. On its own, each polymorphism showed no association with atopic eczema. The 2 polymorphisms were used to generate haplotypes, and a significant result was found for the -590C/-34C haplotype. However, after Bonferroni correction for multiple testing, the association became nonsignificant. Neither polymorphism predisposes to early-onset atopic eczema by itself, but suggestive linkage was found for the -590C/-34C haplotype in this study.

【 授权许可】

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