IgE, mast cells, basophils, and eosinophils

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:125

Article

Stone, Kelly D.¹  Prussin, Calman¹  Metcalfe, Dean D.¹ 

[1] NIAID, Lab Allerg Dis, NIH, Bethesda, MD 20892 USA

关键词: IgE;    mast cells;    basophils;    allergy;    mastocytosis;    hypereosinophilic;    syndromes;   

DOI  :  10.1016/j.jaci.2009.11.017

来源: Elsevier

【 摘 要 】

IgE, mast cells, basophils, and eosinophils are essential components of allergic inflammation. Antigen-specific IgE production, with subsequent fixation of IgE to Fc epsilon RI receptors on mast cells and basophils, is central to the initiation and propagation of immediate hypersensitivity reactions. Mast cells, basophils, and eosinophils are central effector cells in allergic inflammation, as well as in innate and adaptive immunity. This review highlights what is known about these components and their roles in disease pathogenesis. (J Allergy Clin Immunol 2010;125:S73-80.)

【 授权许可】

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