Respiratory allergy caused by house dust mites: What do we really know?

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:136

Article

Calderon, Moises A.¹  Linneberg, Allan^2,3,4  Kleine-Tebbe, Joerg⁵  De Blay, Frederic⁶  Hernandez Fernandez de Rojas, Dolores⁷  Virchow, Johann Christian⁸  Demoly, Pascal^9,10 

[1] Univ London Imperial Coll Sci Technol & Med, NHLI, Royal Brompton Hosp, Sect Allergy & Clin Immunol, London SW3 6LY, England

[2] Capital Reg Denmark, Res Ctr Prevent & Hlth, Copenhagen, Denmark

[3] Glostrup Univ Hosp, Dept Clin Expt Res, Glostrup, Denmark

[4] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, DK-1168 Copenhagen, Denmark

[5] Ackermann & Kleine Tebbe, Allergy & Asthma Ctr Westend, Outpatient Clin Hanf, Berlin, Germany

[6] Univ Strasbourg, Federat Med Translat, Hop Univ Strasbourg, Chest Dis Dept, Strasbourg, France

[7] IIS Hosp La Fe, Dept Allergy, Valencia, Spain

[8] Univ Klinikum Rostock, Zentrum Innere Med 1, Dept Pneumol & Intens Care Med, Rostock, Germany

[9] Univ Hosp Montpellier, Div Allergy, Dept Pulmonol, Paris, France

[10] Univ Paris 04, Paris, France

关键词: Allergen;    house dust mite;    allergy;    allergic asthma;    allergic rhinitis;    respiratory allergic disease;    inflammation;   

DOI  :  10.1016/j.jaci.2014.10.012

来源: Elsevier

【 摘 要 】

The house dust mite (HDM) is a major perennial allergen source and a significant cause of allergic rhinitis and allergic asthma. However, awareness of the condition remains generally low. This review assesses the links between exposure to HDM, development of the allergic response, and pathologic consequences in patients with respiratory allergic diseases. We investigate the epidemiology of HDM allergy to explore the interaction between mites and human subjects at the population, individual, and molecular levels. Core and recent publications were identified by using house dust mite'' as a key search term to evaluate the current knowledge of HDM epidemiology and pathophysiology. Prevalence data for HDM allergen sensitization vary from 65 to 130 million persons in the general population worldwide to as many as 50% among asthmatic patients. Heterogeneity of populations, terminology, and end points in the literature confound estimates, indicating the need for greater standardization in epidemiologic research. Exposure to allergens depends on multiple ecological strata, including climate and mite microhabitats within the domestic environment, with the latter providing opportunity for intervention measures to reduce allergen load. Inhaled mite aeroallergens are unusually virulent: they are able to activate both the adaptive and innate immune responses, potentially offering new avenues for intervention. The role of HDM allergens is crucial in the development of allergic rhinitis and asthma, but the translation of silent sensitization into symptomatic disease is still incompletely understood. Improved understanding of HDMs, their allergens, and their microhabitats will enable development of more effective outcomes for patients with HDM allergy.

【 授权许可】

Free