Genetics of allergen-induced asthma

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:108

Review

Daser, A ; Daheshia, M ; De Sanctis, GT

关键词: airway hyperresponsiveness;    antigen;    asthma;    genetics;    inflammation;    linkage;   

DOI  :  10.1067/mai.2001.116987

来源: Elsevier

【 摘 要 】

Antigen-induced airway hyperresponsiveness and airway inflammation are features of both human asthma and animal models of this disease. The genesis of these key asthma phenotypes represents the summation of a complex cascade of immune responses. It is hypothesized that multiple cell types are involved in the induction, propagation, and maintenance of these immune processes. Several molecules have been reported to be essential for cell-cell interactions, inflammatory cell recruitment; and effector functions leading to the overall expression of the asthmatic phenotype. This review summarizes the genetic evidence supporting a role for these molecules in antigen-driven airway hyperresponsiveness and inflammation.

【 授权许可】

Free