The natural history of soy allergy

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:125

Article

Savage, Jessica H.¹  Kaeding, Allison J.²  Matsui, Elizabeth C.²  Wood, Robert A.² 

[1] Johns Hopkins Univ, Sch Med, Dept Med, Div Allergy & Clin Immunol, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Sch Med, Dept Pediat, Div Allergy & Immunol, Baltimore, MD 21218 USA

关键词: Soy;    soy allergy;    food allergy;    IgE;    tolerance;    natural history;   

DOI  :  10.1016/j.jaci.2009.12.994

来源: Elsevier

【 摘 要 】

Background: Soy allergy is very common, affecting approximately 0.4% of children. It is generally thought that the majority of children with soy allergy develop tolerance in early childhood; however, this has not been examined in a large cohort with soy allergy. Objective: We sought to describe the natural history of soy allergy and identify predictors of oral tolerance/outgrowing soy allergy. Methods: The records of patients with soy allergy seen in a tertiary referral clinic were reviewed. Data collected included soy allergy related symptoms, history of other food allergies and atopic diseases, soy-specific IgE levels, peanut-specific IgE levels, and food challenge results. Results: One hundred thirty-three patients were studied (96 male and 37 female patients). Eighty-five (64%) had asthma, 95 (71%) had allergic rhinitis, and 108 (85%) had atopic dermatitis. Eighty-eight percent had concomitant peanut allergy. The median age at the initial visit was 1 year (range, 2 months to 17.5 years); the median duration of follow-up was 5 years (range, 1-19 years). Kaplan-Meier analysis predicted resolution of soy allergy in 25% by age 4 years, 45% by age 6 years, and 69% by age 10 years. By age 6 years, 59% of children with a peak soy IgE level of less than 5 kU/L, 53% of children with a peak s-IgE level of 5 to 9.9 kU/L, 45% of children with a peak s-IgE level of 10 to 49.9 kU/L, and 18% of children with a peak s-IgE level of greater than 50 kU/L had outgrown soy allergy (P < .01 for trend). Conclusions: In this referral population approximately 50% of children with soy allergy outgrew their allergy by age 7 years. Absolute soy IgE levels were useful predictors of outgrowing soy allergy. (J Allergy Clin Immunol 2010;125:683-6.)

【 授权许可】

Free