Food Allergen-induced IgE Response Mouse Model Created by Injection ofin vitro Differentiated Th2 Cell Culture and Oral AntigenIntake

Bioscience of Microbiota, Food and Health

Takachika HIROI²  Akio MORI³  Kyoko SHIBAHARA¹  Haruyo NAKAJIMA-ADACHI¹  Satoshi HACHIMURA¹  Osamu KAMINUMA² 

[1] Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan;Department of Genome Medicine, Pollen Allergy Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6, Kamikitazawa, Setagaya-ku, Tokyo 156-8506, Japan;Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, 18-1 Sakuradai, Sagamihara-shi, Kanagawa 252-0392, Japan

关键词: Th2 cell;    IgE;    food allergy;   

DOI  :  10.12938/bmfh.33.41

学科分类：生物科学（综合）

来源: Nihon Bifizusukin Senta / Japan Bifidus Foundation

【 摘 要 】

References(15)Immunoglobulin (Ig) E is a mediator of food allergic reaction; however, the mechanisms ofits production in response to an ingested antigen are not fully understood. For analysisof IgE production, here we propose an IgE response mouse model created by injection of aTh2 cell culture and feeding of an egg white diet. According to this manipulation, totaland ovalbumin specific IgE production were elevated in this model. We think our modelenables us to analyze IgE induction by Th2 cells in food allergy and can contribute to thedevelopment of a treatment for food allergy.

【 授权许可】

Unknown