The contributions of allergic sensitization and respiratory pathogens to asthma inception

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:137

Article

Jackson, Daniel J.¹  Gern, James E.^1,2  Lemanske, Robert F., Jr.^1,2 

[1] Univ Wisconsin, Sch Med & Publ Hlth, Dept Pediat, Madison, WI 53706 USA

[2] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Madison, WI 53706 USA

关键词: Asthma;    viruses;    bacteria;    childhood;    rhinovirus;    respiratory syncytial virus;    allergic sensitization;    inflammation;   

DOI  :  10.1016/j.jaci.2016.01.002

来源: Elsevier

【 摘 要 】

Of the chronic diseases affecting grade-school children, asthma is the most common and accounts for the greatest number of school days missed. Moreover, it can influence family dynamics and function in other ways, and unfortunately, it can also be associated with mortality, particularly in the inner-city environments of the United States. Thus understanding factors that lead to its development in early life is essential in developing strategies aimed at primary prevention. Two risk factors that have been identified by a number of investigators include the development of allergic sensitization and wheezing respiratory tract illnesses caused by viruses and bacteria, either !alone or in combination. Both of these factors appear to exert their influences within the first few years of life, such that asthma becomes established before the child enters grade school at age 5 to 6 years. Therefore, because both allergic sensitization and viral and bacterial illnesses can occur in children who do not have asthma, it is paramount to identify genetic and environmental factors that activate, interact with, and/or direct the immune system and components of the respiratory tract along pathways that allow asthma to become established and expressed clinically.

【 授权许可】

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