Interleukin 32: a novel player in the control of infectious diseases

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

Saar Gomes, Rodrigo⁴  Santos, Jé⁵  Lima Silva, Lucas Luiz⁶  Joosten, Leo A. B.⁷  ssica Cristina⁹ 

[1] and;and..Department of Internal Medicine and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands;Department of Internal Medicine and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, The Netherlands;Instituto de Patologia Tropical e Saública, Universidade Federal Goiáde Púnia, Goiás, Brazil;s, Goiâ

关键词: cytokines;    bacteria;    viruses;   

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Interleukin 32 (IL-32) is a proinflammatory cytokine, expressed as 9 distinct isoforms. The most active isoform is the predominantly intracellular-functioning IL-32γ. Involvement of IL-32 in infectious diseases is increasingly being appreciated. Production of IL-32 promotes pathways that serve to control bacterial infection, especially those caused by mycobacteria. A similar role for this cytokine is observed in the cellular response to viral infections. In addition to its protective effects against microorganisms, IL-32 is involved in immunopathogenesis of some infectious diseases. In parasitic diseases, it has been demonstrated that this cytokine is induced by Leishmania infection. In this review, we summarize the present data on the role of IL-32 in infectious diseases, highlighting this cytokine as new target for control of infections.

【 授权许可】

CC BY