IL-22-producing T22 T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:123

Article

Nograles, Kristine E.¹  Zaba, Lisa C.¹  Shemer, Avner²  Fuentes-Duculan, Judilyn¹  Cardinale, Irma¹  Kikuchi, Toyoko¹  Ramon, Michal³  Bergman, Reuven³  Krueger, James G.¹  Guttman-Yassky, Emma^1,4 

[1] Rockefeller Univ, Lab Investigat Dermatol, New York, NY 10065 USA

[2] Tel Hashomer Med Ctr, Dept Dermatol, Ramat Gan, Israel

[3] Rambam Med Ctr & Techn, Dept Dermatol, Haifa, Israel

[4] Cornell Univ, Weill Cornell Med Coll, Dept Dermatol, New York, NY 10021 USA

关键词: Atopic dermatitis;    psoriasis;    T(H)17;    IL-17;    IL-22;    T22;   

DOI  :  10.1016/j.jaci.2009.03.041

来源: Elsevier

【 摘 要 】

Background: Psoriasis and atopic dermatitis (AD) are common inflammatory skin diseases. An upregulated T(H)17/IL-23 pathway was demonstrated in psoriasis. Although potential involvement of T(H)17 T cells in AD was suggested during acute disease, the role of these cells in chronic AD remains unclear. Objective: To examine differences in IL-23/T(H)17 signal between these diseases and establish relative frequencies of T-cell subsets in AD. Methods: Skin biopsies and peripheral blood were collected from patients with chronic AD (n = 12) and psoriasis (n = 13). Relative frequencies of CD4(+) and CD8(+) T-cell subsets within these 2 compartments were examined by intracellular cytokine staining and flow cytometry. Results: In peripheral blood, no significant difference was found in percentages of different T-cell subsets between these diseases. In contrast, psoriatic skin had significantly increased frequencies of T(H)1 and T(H)17 T cells compared with AD, whereas T(H)2 T cells were significantly elevated in AD. Distinct IL-22-producing CD4(+) and CD8(+) T-cell populations were significantly increased in AD skin compared with psoriasis. IL-22(+)CD8(+) T-cell frequency correlated with AD disease severity. Conclusion: Our data established that T cells could independently express IL-22 even with low expression levels of IL-17. This argues for a functional specialization of T cells such that T17 and T22 T-cells may drive different features of epidermal pathology in inflammatory skin diseases, including induction of antimicrobial peptides for T17 T cells and epidermal hyperplasia for T22 T-cells. Given the clinical correlation with disease severity, further characterization of T22 T cells is warranted, and may have future therapeutic implications. (J Allergy Clin Immunol 2009;123:1244-52.)

【 授权许可】

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