Biologics for chronic rhinosinusitis with nasal polyps

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:145

Review

Bachert, Claus^1,2,3,4  Zhang, Nan^1,2,3  Cavaliere, Carlo⁵  Wen Weiping¹  Gevaert, Elien^2,3  Krysko, Olga^2,3 

[1] Sun Yat Sen Univ, Affiliated Hosp 1, Int Airway Res Ctr, 58 Zhong Shan Er Lu, Guangzhou 510080, Peoples R China

[2] Univ Ghent, Upper Airways Res Lab, Ghent, Belgium

[3] Univ Ghent, Dept Otorhinolaryngol, Ghent, Belgium

[4] Univ Stockholm, Karolinska Inst, Div ENT Dis, CLINTEC, Stockholm, Sweden

[5] Sapienza Univ Rome, Dept Oral & Maxillofacial Sci, Rome, Italy

关键词: Chronic rhinosinusitis;    nasal polyps;    endotypes;    type 2 inflammation;    biologics;   

DOI  :  10.1016/j.jaci.2020.01.020

来源: Elsevier

【 摘 要 】

With the increasing recognition of the role of type 2 immune responses in chronic rhinosinusitis, its severity, recurrence, and comorbidities, several biologics targeting IL-4, IL-5, and IL-13 as well as IgE have been administered in small proof-of-concept studies. Recently, the first phase 3 trials have been reported with dupilumab, an IL-4 receptor antagonist, demonstrating a significant and clinically relevant reduction of the disease burden from polyp size and sinus involvement to symptoms and smell; these changes consecutively led to an important increase in quality of life. Finally, the biologic versus placebo treatment reduced the need for systemic glucocorticosteroids and sinus surgery significantly and clinically meaningfully. Dupilumab today is registered for the treatment of chronic rhinosinusitis with nasal polyps in Europe and the United States. Within a year, 2 further phase 3 trials with omalizumab and mepolizumab will be reported. With this development, without any doubt, a new era for the treatment of severe uncontrolled chronic rhinosinusitis with nasal polyps has begun. Questions on the indication of the biologics, the selection of patients, and finally criteria for monitoring the efficacy in individual patients need to be urgently answered, and care pathways need to be established integrating the current standard of care including surgery.

【 授权许可】

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