Role of costimulatory pathways in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:112

Review

Chitnis, T ; Khoury, SJ

关键词: B7-1;    B7-2;    CD28;    CD40;    CD137 (4-IBB);    CD154;    (CD40 ligand);    costimulation;    CTLA-4 (CD152);    CTLA41g;    experimental autoimmune encephalomyelitis;    inducible costimulatory molecule;    multiple sclerosis;    programmed death pathway 1;    programmed death pathway ligand 1;    programmed death pathway ligand 2;    OX40 (CD134);    OX40 ligand (CD134L);   

DOI  :  10.1016/j.jaci.2003.08.025

来源: Elsevier

【 摘 要 】

Multiple sclerosis is an immune-mediated disorder of the central nervous system. T lymphocytes are thought to play a central role in the initiation and potentially in the propagation of this disease. Two signals are required for T-cell activation. The first signal consists of the interaction of the T-cell receptor with antigen presented by the MHC molecule on antigen-presenting cells. The second signal requires engagement of costimulatory receptors on T cells with their ligands on antigen-presenting cells. Several costimulatory pathways have been shown to play an important role in T-lymphocyte activation. Here we will review the current literature on the contribution of the B7-1/2-CD28/CTLA-4, inducible costimulatory molecule-B7h, programmed death pathway 1-programmed death pathway ligand 1/ligaDd 2, CD40-CD154, OX40-OX40 ligand, and CD137-CD137 ligand pathways to the pathogenesis of multiple sclerosis and their potential roles as therapeutic targets.

【 授权许可】

Free