Is the prevalence of peanut allergy increasing? A 5-year follow-up study in children in Montreal

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:123

Article

Ben-Shoshan, Moshe¹  Kagan, Rhoda S.²  Alizadehfar, Reza¹  Joseph, Lawrence^3,4,5  Turnbull, Elizabeth³  St Pierre, Yvan³  Clarke, Ann E.^4,5 

[1] McGill Univ, Hlth Ctr, Division of Clin Immunol Allergy & Rheumatol, Dept Pediat, Montreal, PQ H3A 2T5, Canada

[2] Univ Toronto, N York Gen Hosp, Dept Pediat, Toronto, ON, Canada

[3] McGill Univ, Hlth Ctr, Dept Med, Div Clin Epidemiol, Montreal, PQ H3A 2T5, Canada

[4] McGill Univ, Dept Epidemiol & Biostat, Montreal, PQ H3A 2T5, Canada

[5] McGill Univ, Hlth Ctr, Div Clin Epidemiol & Clin Immunol Allergy, Dept Med, Montreal, PQ H3A 2T5, Canada

关键词: Peanut allergy;    prevalence;    skin prick test;    peanut-specific IgE;    food challenge;    epidemiology;   

DOI  :  10.1016/j.jaci.2009.02.004

来源: Elsevier

【 摘 要 】

Background: Studies suggest that peanut allergy prevalence might be increasing, but these results have not yet been substantiated. Objective: We conducted a follow-up study to determine whether peanut allergy prevalence in Montreal is increasing. Methods: Questionnaires regarding peanut ingestion were administered to parents of children in randomly selected kindergarten through grade 3 classrooms between December 2000 and September 2002 and between October 2005 and December 2007. Respondents were stratified as (1) peanut tolerant, (2) never/rarely ingest peanut, (3) convincing history of peanut allergy, or (4) uncertain history of peanut allergy. Children in group 3 with positive skin prick test responses were considered to have peanut allergy. Children in groups 2 and 4 with positive skin prick test responses had peanut-specific IgE levels measured, and if the value was less than 15 kU/L, an oral peanut challenge was performed. Multiple imputation was used to generate prevalence estimates that incorporated respondents providing incomplete data and nonrespondents. Results: Of 8,039 children surveyed in 2005-2007, 64.2% of parents responded. Among those providing complete data, the prevalence was 1.63% (95% CI, 1.30% to 2.02%) in 2005-2007 versus 1.50% (95% CI, 1.16% to 1.92%) in 2000-2002. After adjustment for missing data, the prevalence was 1.62% (95% credible interval, 1.31% to 1.98%) versus 1.34% (95% credible interval, 1.08% to 1.64%), respectively. The differences between the prevalences in 2005-2007 and 2000-2002 were 0.13% (95% credible interval, 20.38% to 0.63%) among those providing complete data and 0.28% (95% credible interval, 20.15 % to 0.70 %) after adjustment for missing data. Conclusions: This is the first North American study to document temporal trends in peanut allergy prevalence by corroborating history with confirmatory tests. The results suggest a stable prevalence, but wide CIs preclude definitive conclusions. (J Allergy Clin Immunol 2009;123:783-8.)

【 授权许可】

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