Mast cell-T cell interactions

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:104

Article

Mekori, YA ; Metcalfe, DD

关键词: mast cell;    T cell;    adhesion;    antigen presentation;    chemotaxis;    cytokines;    degranulation;    migration;   

DOI  :  10.1016/S0091-6749(99)70316-7

来源: Elsevier

【 摘 要 】

In addition to being a major effector cell in the elicitation of allergic inflammation, mast cells have been found to be activated in various T cell-mediated inflammatory processes and to reside in close physical proximity to T cells, Such observations and the wide spectrum of mediators produced and secreted by mast cells have led investigators to propose a functional relationship between these 2 cell populations. Indeed, mast cell activation has been reported to induce T-cell migration either directly by the release of chemotactic factors, such as lymphotactin or IL-16, or indirectly by the induction of adhesion molecule expression on endothelial cells, Mast cells are also able to present antigens to T cells, resulting in their activation in either an MHC class I- or class II-restricted and costimulatory molecule-dependent fashion. Adhesion molecule-dependent intercellular contact or MHC class II cognate interactions between T cells and mast cells result in the release of both granule-associated mediators and cytokines from the latter, Also, T cell-derived mediators, such as beta-chemokines, directly induce mast cell degranulation, On the other hand, mast cell-derived cytokines, such as IL-4, have been found to polarize T cells to preferentially differentiate into the T-H2 subset. Thus T cell-mast fell interactions are bidirectional, fulfilling regulatory and/or modulatory roles affecting various aspects of the immune response.

【 授权许可】

Free