Mast Cell Functions Linking Innate Sensing to Adaptive Immunity

Cells

Johanna Kotrba¹  Martin Voss¹  Jan Dudeck¹  Anne Dudeck¹  Konstantinos Katsoulis-Dimitriou¹ 

[1] Institute for Molecular and Clinical Immunology, Otto-von-Guericke Universität Magdeburg, 39120 Magdeburg, Germany;

关键词: mast cell;    adaptive immunity;    dendritic cell;    T cell;    antigen presentation;   

DOI  :  10.3390/cells9122538

来源: DOAJ

【 摘 要 】

Although mast cells (MCs) are known as key drivers of type I allergic reactions, there is increasing evidence for their critical role in host defense. MCs not only play an important role in initiating innate immune responses, but also influence the onset, kinetics, and amplitude of the adaptive arm of immunity or fine-tune the mode of the adaptive reaction. Intriguingly, MCs have been shown to affect T-cell activation by direct interaction or indirectly, by modifying the properties of antigen-presenting cells, and can even modulate lymph node-borne adaptive responses remotely from the periphery. In this review, we provide a summary of recent findings that explain how MCs act as a link between the innate and adaptive immunity, all the way from sensing inflammatory insult to orchestrating the final outcome of the immune response.

【 授权许可】

Unknown