Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:146

Article

Yang, Yang¹  Shen, Chenguang¹  Li, Jinxiu¹  Yuan, Jing¹  Wei, Jinli¹  Huang, Fengmin²  Wang, Fuxiang¹  Li, Guobao¹  Li, Yanjie¹  Xing, Li¹  Peng, Ling¹  Yang, Minghui¹  Cao, Mengli¹  Zheng, Haixia¹  Wu, Weibo¹  Zou, Rongrong¹  Li, Delin¹  Xu, Zhixiang¹  Wang, Haiyan¹  Zhang, Mingxia¹  Zhang, Zheng¹  Gao, George F.³  Jiang, Chengyu²  Liu, Lei¹  Liu, Yingxia¹ 

[1] Southern Univ Sci & Technol, Hosp 2, Shenzhen Peoples Hosp 3,State Key Discipline Infe, Shenzhen Key Lab Pathogen & Immun,Natl Clin Res C, Shenzhen, Peoples R China

[2] Chinese Acad Med Sci, Peking Union Med Coll, Dept Biochem, State Key Lab Med Mol Biol,Inst Basic Med Sci, Beijing, Peoples R China

[3] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China

关键词: COVID-19;    SARS-CoV-2;    biomarkers;    disease progression;    prediction;   

DOI  :  10.1016/j.jaci.2020.04.027

来源: Elsevier

【 摘 要 】

Background: The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 was first reported in Wuhan, December 2019, and continuously poses a serious threat to public health, highlighting the urgent need of identifying biomarkers for disease severity and progression. Objective: We sought to identify biomarkers for disease severity and progression of COVID-19. Methods: Forty-eight cytokines in the plasma samples from 50 COVID-19 cases including 11 critically ill, 25 severe, and 14 moderate patients were measured and analyzed in combination with clinical data. Results: Levels of 14 cytokines were found to be significantly elevated in COVID-19 cases and showed different expression profiles in patients with different disease severity. Moreover, expression levels of IFN-gamma-induced protein 10, monocyte chemotactic protein-3, hepatocyte growth factor, monokine-induced gamma IFN, and macrophage inflammatory protein 1 alpha, which were shown to be highly associated with disease severity during disease progression, were remarkably higher in critically ill patients, followed by severe and then the moderate patients. Serial detection of the 5 cytokines in 16 cases showed that continuously high levels were associated with deteriorated progression of disease and fatal outcome. Furthermore, IFN-gamma-induced protein 10 and monocyte chemotactic protein-3 were excellent predictors for the progression of COVID-19, and the combination of the 2 cytokines showed the biggest area under the curve of the receiver-operating characteristics calculations with a value of 0.99. Conclusions: In this study, we report biomarkers that are highly associated with disease severity and progression of COVID-19. These findings add to our understanding of the immunopathologic mechanisms of severe acute respiratory syndrome coronavirus 2 infection, and provide potential therapeutic targets and strategies.

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