Sex-Related Factors in Cardiovascular Complications Associated to COVID-19

Biomolecules

Eleni Anastasiadou¹  Paola Pontecorvi¹  Giulia Gerini¹  Cinzia Marchese¹  Simona Ceccarelli¹  Francesca Megiorni¹ 

[1] Department of Experimental Medicine, “Sapienza” University of Rome, Viale Regina Elena 324, 00161 Rome, Italy;

关键词: SARS-CoV-2;    COVID-19;    cardiovascular diseases;    sex;    gender;    biomarkers;   

DOI  :  10.3390/biom12010021

来源: DOAJ

【 摘 要 】

Coronavirus disease 2019 (COVID-19), the pandemic infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), presents with an extremely heterogeneous spectrum of symptoms and signs. The clinical manifestations seem to be correlated with disease severity. COVID-19 susceptibility and mortality show a significant sex imbalance, with men being more prone to infection and showing a higher rate of hospitalization and mortality compared to women. Such variability can be ascribed to both sex-related biological factors and gender-related behavioral cues. This review will discuss the potential mechanisms accounting for sex/gender influence in vulnerability to COVID-19. Cardiovascular diseases play a central role in determining COVID-19 outcome, whether they are pre-existent or arose upon infection. We will pay particular attention to the impact of sex and gender on cardiovascular manifestations related to COVID-19. Finally, we will discuss the sex-dependent variability in some biomarkers for the evaluation of COVID-19 infection and prognosis. The aim of this work is to highlight the significance of gendered medicine in setting up personalized programs for COVID-19 prevention, clinical evaluation and treatment.

【 授权许可】

Unknown