Mas-related G protein-coupled receptor X2 and its activators in dermatologic allergies

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:147

Review

Kuehn, Helen¹  Kolkhir, Pavel^2,3,4,5,6  Babina, Magda^2,3,4,5  Duell, Miriam¹  Frischbutter, Stefan^2,3,4,5  Fok, Jie Shen^2,3,4,5,7,8  Jiao, Qingqing^2,3,4,5,9  Metz, Martin^2,3,4,5  Scheffel, Jorg^2,3,4,5  Wolf, Katharina¹  Kremer, Andreas E.¹  Maurer, Marcus^2,3,4,5 

[1] Friedrich Alexander Univ Erlangen Nurnberg, Dept Med 1, Erlangen, Germany

[2] Charite Univ Med Berlin, Dept Dermatol & Allergy, Allergie Ctr Charite, Dermatol Allergol, Berlin, Germany

[3] Free Univ Berlin, Berlin, Germany

[4] Humboldt Univ, Berlin, Germany

[5] Berlin Inst Hlth, Berlin, Germany

[6] IM Sechenov First Moscow State Med Univ, Sechenov Univ, Div Immune Mediated Skin Dis, Moscow, Russia

[7] Box Hill Hosp, Dept Resp Med, Melbourne, Vic, Australia

[8] Monash Univ, Fac Med Nursing & Hlth Sci, Melbourne, Vic, Australia

[9] Soochow Univ, Affiliated Hosp 1, Dept Dermatol, Suzhou, Peoples R China

关键词: MRGPRX2;    MRGX2;    agonists;    chronic spontaneous urticaria;    atopic dermatitis;    substance P;    neuropeptides;    eosinophil granule proteins;    antimicrobial peptides;    pruritus;    itch;   

DOI  :  10.1016/j.jaci.2020.08.027

来源: Elsevier

【 摘 要 】

The Mas-related G protein-coupled receptor X2 (MRGPRX2) is a multiligand receptor responding to various exogenous and endogenous stimuli. Being highly expressed on skin mast cells, MRGPRX2 triggers their degranulation and release of proinflammatory mediators, and it promotes multicellular signaling cascades, such as itch induction and transmission in sensory neurons. The expression of MRGPRX2 by skin mast cells and the levels of the MRGPRX2 agonists (eg, substance P, major basic protein, eosinophil peroxidase) are upregulated in the serum and/or skin of patients with inflammatory and pruritic skin diseases, such as chronic spontaneous urticaria or atopic dermatitis. Therefore, MRGPRX2 and its agonists might be potential biomarkers for the progression of cutaneous inflammatory diseases and the response to treatment. In addition, they may represent promising targets for prevention and treatment of signs and symptoms in patients with skin diseases or drug reactions. To assess this possibility, this review explores the role and relevance of MRGPRX2 and its activators in cutaneous inflammatory disorders and chronic pruritus.

【 授权许可】

Free