Gemini pyridinium amphiphiles for the synthesis and stabilization of gold nanoparticles for drug delivery

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:502

Article

Alea-Reyes, Maria E.^1,2  Gonzalez, Asensio¹  Calpena, Ana C.^1,2,3  Ramos-Lopez, David⁴  de lapuente, Joaquin⁴  Perez-Garcia, Lluisa^1,2,5 

[1] Univ Barcelona, Dept Farmacol Toxicol & Quim Terapeut, E-08028 Barcelona, Spain

[2] Univ Barcelona, Inst Nanociencia & Nanotecnol IN2UB, E-08028 Barcelona, Spain

[3] Univ Barcelona, Dept Farm & Tecnol Farmaceut & Fisicoquim, E-08028 Barcelona, Spain

[4] Unitat Toxicol Expt & Ecotoxicol UTOX PCB, Baldiri & Reixac 10-12, Barcelona 08028, Spain

[5] Univ Nottingham, Sch Pharm, Nottingham NG7 2RD, England

关键词: Gemini pyridinium amphiphiles;    Tetrahydropyridines;    Gold nanoparticles;    Anionic drug encapsulation;   

DOI  :  10.1016/j.jcis.2017.04.064

来源: Elsevier

【 摘 要 】

Hypothesis: Gemini pyridinium-based amphiphiles can play a triple role as: gold nanoparticles (AuNPs) synthesis facilitator, particle stabilizer and anion recognition centre. The so formed nanoparticles should be able to bind and release anionic drugs. Experiments: We describe (a) Synthesis, by a phase transfer method, of both new organic media and water soluble AuNPs using gemini-type surfactants based on bis-pyridinium salts as ligands, acting as transfer agents into organic media and also as nanoparticle stabilizers, (b) Examination of their stability in solution, (c) Chemical and physical characterization of the nanoparticles, (d) Toxicity data concerning both the bis-pyridinium ligands and the bis-pyridinium coated nanoparticles, and (e) Study of their ability for delivering anionic pharmaceuticals such as ibuprofen and piroxicam. Findings: Pyridinium gemini-type surfactants show the ability to play multiple roles such as transfer agent and stabilizer, as well as ionophores: They are responsible for the preparation, stability, and delivery properties of these AuNPs, which gold core is stabilized by the anions present in the bispyridinium salts. The tetrahydropyridine resulting from the reduction of the bis-pyridinium salt is capable of reduce gold, due to its spontaneous oxidation to the corresponding pyridinium salt, leading to the formation of stable AuNPs. (C) 2017 Elsevier Inc. All rights reserved.

【 授权许可】

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