Nano-TiCl4/SiO2: An efficient heterogeneous solid acid catalyst for the one pot cascade five-component synthesis of densely functionalized tetrahydropyridines

Journal of Chemical Sciences

Abdolhamid Bamoniri1¹  Reza Tarazian¹  Bi Bi Fatemeh Mirjalili² 

[1] Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R. Iran$$;Department of Chemistry, College of Science, Yazd University, Yazd, I. R. Iran$$

关键词: Tetrahydropyridines;    Nano-TiCl4/SiO2;    heterogeneous catalyst;    five-component reaction;    onepot synthesis.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Nano-TiCl4/SiO2 was found to be an inexpensive and efficient heterogeneous solid acid catalyst for the synthesis of one-pot cascade synthesis of highly functionalized asymmetric tetrahydropyridines from the five-component condensation reaction of the para-substituted anilines and aromatic aldehydes with ethyl acetoacetate under thermal conditions. Novel methodology, environmentally benign conditions, clean protocol, easy work-up and high yields are the important advantages of this protocol. The products were characterized using physical and spectroscopic data such as FT-IR, 1H-NMR and in some cases 13C-NMR and CHN analysis.

【 授权许可】

Unknown