Assembling patchy plasmonic nanoparticles with aggregation-dependent antibacterial activity

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:580

Article

Brasili, Francesco^1,2  Capocefalo, Angela¹  Palmieri, Damiano^1,2  Capitani, Francesco³  Chiessi, Ester²  Paradossi, Gaio²  Bordi, Federico^1,4,5  Domenici, Fabio² 

[1] Sapienza Univ Roma, Dipartimento Fis, Piazzale Aldo Moro 5, I-00185 Rome, Italy

[2] Univ Roma Tor Vergata, Dipartimento Sci & Tecnol Chim, Via Ric Sci, I-00133 Rome, Italy

[3] Synchrotron SOLEIL, F-91192 Gif Sur Yvette, France

[4] Sapienza Univ Roma, CNR ISC UOS Roma, Piazzale Aldo Moro 5, I-00185 Rome, Italy

[5] Sapienza Univ Roma, CNIS Nanotechnol Res Ctr Appl Engn, Piazzale Aldo Moro 5, I-00185 Rome, Italy

关键词: Gold nanoparticles;    Nanozyme;    Patchy colloids;    Plasmonics;    Self-assembly;    Functional nanomaterials;    Antibacterial activity;    Protein-nanoparticle interaction;   

DOI  :  10.1016/j.jcis.2020.07.006

来源: Elsevier

【 摘 要 】

We realise an antibacterial nanomaterial based on the self-limited assembly of patchy plasmonic colloids, obtained by adsorption of lysozyme to gold nanoparticles. The possibility of selecting the size of the assemblies within several hundred nanometres allows for tuning their optical response in a wide range of frequencies from visible to near infrared. We also demonstrate an aggregation-dependent modulation of the catalytic activity, which results in an enhancement of the antibacterial performances for assemblies of the proper size. The gained overall control on structure, optical properties and biological activity of such nanomaterial paves the way for the development of novel antibacterial nanozymes with promising applications in treating multi drug resistant bacteria. (C) 2020 Elsevier Inc. All rights reserved.

【 授权许可】

Free