Glass capillary microfluidics for production of monodispersed poly (DL-lactic acid) and polycaprolactone microparticles: Experiments and numerical simulations

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:418

Article

Vladisavljevic, Goran T.¹  Shahmohamadi, Hamed²  Das, Diganta B.¹  Ekanem, E. Ekanem¹  Tauanov, Zhandos¹  Sharma, Lay¹ 

[1] Univ Loughborough, Dept Chem Engn, Loughborough LE11 3TU, Leics, England

[2] Univ Loughborough, Wolfson Sch Mech & Mfg Engn, Loughborough LE11 3TU, Leics, England

关键词: Drop microfluidics;    Flow focusing;    Poly(lactic acid);    Polycaprolactone;    Monodispersed microparticle;    Ultrasound contrast agent;    Computational fluid dynamics;    Porous particle;    Lidocaine hydrochloride;    Controlled drug release;   

DOI  :  10.1016/j.jcis.2013.12.002

来源: Elsevier

【 摘 要 】

Hypothesis: Droplet size in microfluidic devices is affected by wettability of the microfluidic channels. Three-dimensional countercurrent flow focusing using assemblies of chemically inert glass capillaries is expected to minimize wetting of the channel walls by the organic solvent. Experiments: Monodispersed polycaprolactone and poly(lactic acid) particles with a diameter of 18-150 mu m were produced by evaporation of solvent (dichloromethane or 1:2 mixture of chloroform and toluene) from oil-in-water or water-in-oil-in-water emulsions produced in three-dimensional flow focusing glass capillary devices. The drop generation behaviour was simulated numerically using the volume of fluid method. Findings: The numerical results showed good agreement with high-speed video recordings. Monodispersed droplets were produced in the dripping regime when the ratio of the continuous phase flow rate to dispersed phase flow rate was 5-20 and the Weber number of the dispersed phase was less than 0.01. The porosity of polycaprolactone particles increased from 8 to 62% when 30 wt% of the water phase was incorporated in the organic phase prior to emulsification. The inner water phase was loaded with 0.156 wt% lidocaine hydrochloride to achieve a sustained drug release. 26% of lidocaine was released after 1 h and more than 93% of the drug was released after 130 h. (C) 2013 Elsevier Inc. All rights reserved.

【 授权许可】

Free