Pluronic F127 thermosensitive injectable smart hydrogels for controlled drug delivery system development

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:565

Article

Shriky, Bana¹  Kelly, Adrian¹  Isreb, Mohammad²  Babenko, Maksims¹  Mahmoudi, Najet³  Rogers, Sarah³  Shebanova, Olga⁴  Snow, Tim⁴  Gough, Tim¹ 

[1] Univ Bradford, Fac Engn & Informat, Fac Life Sci, Bradford, W Yorkshire, England

[2] Univ Bradford, Fac Life Sci, Bradford, W Yorkshire, England

[3] Rutherford Appleton Lab, STFC, ISIS, Didcot, Oxon, England

[4] Rutherford Appleton Lab, STFC, Diamond Light Source, Didcot, Oxon, England

关键词: Thermosensitive;    Gel;    Thermal properties;    Rheological properties;    SAXS;    SANS;    Drug release;    Pluronic;    Colloidal crystals;    Drug delivery systems;    Injectables;   

DOI  :  10.1016/j.jcis.2019.12.096

来源: Elsevier

【 摘 要 】

Understanding structure-property relationships is critical for the development of new drug delivery systems. This study investigates the properties of Pluronic smart hydrogel formulations for future use as injectable controlled drug carriers. The smart hydrogels promise to enhance patient compliance, decrease side effects and reduce dose and frequency. Pharmaceutically, these systems are attractive due to their unique sol-gel phase transition in the body, biocompatibility, safety and injectability as solutions before transforming into gel matrices at body temperature. We quantify the structural changes of F127 systems under controlled temperature after flow, as experienced during real bodily injection. Empirical formulae combining the coupled thermal and shear dependency are produced to aid future application of these systems. Induced structural transitions measured in-situ by small angle x-ray and neutron scattering reveal mixed oriented structures that can be exploited to tailor the drug release profile. (C) 2020 The Authors. Published by Elsevier Inc.

【 授权许可】

Free