Alternating magnetic field mediated release of fluorophores from magnetic nanoparticles by hysteretic heating

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:571

Article

Casey, Jonathan S.¹  Arrizabalaga, Julien H.¹  Abu-Laban, Mohammad²  Becca, Jeffrey C.³  Rose, Benjamin J.¹  Strickland, Kevin T.¹  Bursavich, Jacob B.⁴  McCann, Jacob S.⁵  Pacheco, Carlos N.^3,6  Jensen, Lasse³  Attaluri, Anilchandra⁷  Hayes, Daniel J.^1,8,9 

[1] Penn State Univ, Dept Biomed Engn, University Pk, PA 16802 USA

[2] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

[3] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

[4] Louisiana State Univ, Dept Agr & Biol Engn, Baton Rouge, LA 70803 USA

[5] Penn State Univ, Dept Biochem & Mol Biol, University Pk, PA 16802 USA

[6] Penn State Univ, NMR Facil, University Pk, PA 16802 USA

[7] Penn State Univ, Dept Mech Engn, Harrisburg, PA 17057 USA

[8] Penn State Univ, Mat Res Inst, Millennium Sci Complex, University Pk, PA 16802 USA

[9] Penn State Univ, Huck Inst Life Sci, Millennium Sci Complex, University Pk, PA 16802 USA

关键词: Magnetic;    Nanoparticles;    Diels-Alder;    Controlled release;    Alternating magnetic field;    Iron oxide;   

DOI  :  10.1016/j.jcis.2020.03.056

来源: Elsevier

【 摘 要 】

This study explores the use of differential heating of magnetic nanoparticles with different sizes and compositions (MFe2O4 (M = Fe, Co)) for heteroplexed temporal controlled release of conjugated fluorophores from the surface of nanoparticles. By exploiting these differences, we were able to control the amount of hysteretic heating occurring with the distinct sets of magnetic nanoparticles using the same applied alternating magnetic field radio frequency (AMF-RF). Using thermally labile retro-Diels-Alder linkers conjugated to the surface of nanoparticles, the fluorescent payload from the different nanoparticles disengaged when sufficient energy was locally generated during hysteretic heating. 1H, 13C NMR, ESI-MS, and SIMS characterized the thermally responsive fluorescent cycloadducts used in this study; the Diels Alder cycloadducts were modeled using density functional theory (DFT) computations. The localized point heating of the different nanoparticle compositions drove the retro-Diels-Alder reaction at different times resulting in higher release rates of fluorophores from the CoFe2O4 compared to the Fe3O4 nanoparticles. (C) 2020 Elsevier Inc. All rights reserved.

【 授权许可】

Free