The influence of cation incorporation and leaching in the properties of Mn-doped nanoparticles for biomedical applications

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:578

Article

Garcia-Soriano, David¹  Amaro, Rebeca¹  Lafuente-Gomez, Nuria¹  Milan-Rois, Paula¹  Somoza, Alvaro^1,5  Navio, Cristina¹  Herranz, Fernando^2,3  Gutierrez, Lucia⁴  Salas, Gorka^1,5 

[1] Campus Univ Cantoblanco, IMDEA Nanociencia, Madrid 28049, Spain

[2] CSIC, Inst Quim Med, Juan Cierva 3, Madrid 28006, Spain

[3] CIBERES, Madrid, Spain

[4] Univ Zaragoza, Dept Analyt Chem, INA ICMA & CIBER BBN, C Mariano Esquillor S-N, Zaragoza 50018, Spain

[5] Unidad Asociada Nanobiotecnol CNB CSIC & IMDEA, Madrid, Spain

关键词: Magnetic nanoparticles;    Colloidal ferrites;    Cation doping;    Leaching;    MRI contrast;    Hyperthermia;   

DOI  :  10.1016/j.jcis.2020.06.011

来源: Elsevier

【 摘 要 】

Hypothesis: Superparamagnetic MnxFe3-xO4 nanoparticles are promising materials for applications in biomedicine and other fields. Small variations in the Mn/Fe ratio have a strong impact on the properties of the nanoparticles. Those variations may be caused by the synthesis itself and by common post-synthesis manipulations like surface modification. Experiments: Mn-ferrite nanoparticles have been prepared changing systematically the Mn/Fe ratio of the metal precursors and repeating each reaction three times. Nanoparticles were subjected to surface modification with two different and typical molecules to stabilize them in aqueous media. The discrepancy in the Mn/Fe ratios of the precursors with the ones measured after the synthesis and the surface modification have been studied, as well as its impact on the saturation magnetization, blocking temperature, contrast enhancement for magnetic resonance imaging, magnetic heating, and on the cytotoxicity. Findings: Mn is incorporated in the nanoparticles in a relatively lower amount than Fe and, as this report shows for the first time, both Mn and Fe ions leach out from the nanoparticles during the surface modification step. The blocking temperature decreases exponentially as the Mn/Fe ratio increases. The transverse and longitudinal relaxation times and the magnetic heating ability change appreciably even with small variations in the composition. (C) 2020 Elsevier Inc. All rights reserved.

【 授权许可】

Free