Layer-by-layer assembly of polymersomes and polyelectrolytes on planar surfaces and microsized colloidal particles

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:421

Article

Coustet, Marcos¹  Irigoyen, Joseba²  Alonso Garcia, Teodoro²  Murray, Richard A.²  Romero, Gabriela²  Susana Cortizo, M.¹  Knoll, Wolfgang³  Azzaroni, Omar¹  Moya, Sergio E.² 

[1] UNLP, CONICET, Inst Invest Fis Quim Teor & Aplicadas INIFTA, Dept Quim,Fac Ciencias Exactas, RA-1900 La Plata, Buenos Aires, Argentina

[2] CIC BiomaGUNE, San Sebastian 20009, Spain

[3] AIT, A-1220 Vienna, Austria

关键词: Layer-by-layer assembly;    Colloidal nanomaterials;    Polymersomes;   

DOI  :  10.1016/j.jcis.2014.01.038

来源: Elsevier

【 摘 要 】

Hybrid polyelectrolyte multilayer systems were fabricated on top of planar surfaces and colloidal particles via layer by layer (LbL) assembly of polystyrene sulphonate (PSS) and polybenzyl methacrylateblock-poly(dimethylamino)ethyl methacrylate (PBzMA-b-PDMAEMA) polymersomes. Polymersomes were prepared by self assembly of PBzMA-b-PDMAEMA copolymer, synthesised by group transfer polymerisation. Polymersomes display a diameter of 270 nm and a shell thickness of 11 nm. Assembly on planar surfaces was followed by means of the Quartz Crystal Microbalance with Dissipation (QCM-D) and Atomic Force Microscopy (AFM). Detailed information on the assembly mechanism and surface topology of the polymersome/polyelectrolyte films was thereby obtained. The assembly of polymersomes and PSS on top of silica particles of 500 nm in diameter was confirmed by zeta-potential measurements. Confocal laser scanning microscopy (CLSM), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) revealed that polymersome/PSS coated silica particles increase in total diameter up to 3-5 mu m. This hints toward the formation of densely packed polymersome layers. In addition, CLSM showed that polymersome/PSS films exhibit a high loading capacity that could potentially be used for encapsulation and delivery of diverse chemical species. These results provide an insight into the formation of multilayered films with compartmentalised hydrophilic/hydrophobic domains and may lead to the successful application of polymersomes in surface-engineered colloidal systems. (c) 2014 Elsevier Inc. All rights reserved.

【 授权许可】

Free