Release of small hydrophilic molecules from polyelectrolyte capsules: Effect of the wall thickness

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:447

Article

Cuomo, Francesca^1,2  Lopez, Francesco^1,2  Piludu, Marco³  Miguel, Maria G.^4,6  Lindman, Bjorn^5,6,7  Ceglie, Andrea^1,2 

[1] Univ Molise, Dipartimento Agr, Ambiente Alimenti DIAAA, I-86100 Campobasso, Italy

[2] Univ Molise, CSGI, I-86100 Campobasso, Italy

[3] Univ Cagliari, Dipartimento Sci Biomed, I-09042 Monserrato, CA, Italy

[4] Univ Coimbra, Dept Chem, P-3004535 Coimbra, Portugal

[5] Lund Univ, Phys Chem, S-22100 Lund, Sweden

[6] Nanyang Technol Univ, Sch Mat Sci & Engn, Singapore 639798, Singapore

[7] Mid Sweden Univ, Fibre Sci & Commun Network, Sundsvall, Sweden

关键词: Layer by layer;    Polyelectrolyte nanocapsules;    Multishell thickness;    Molecule release;   

DOI  :  10.1016/j.jcis.2014.10.060

来源: Elsevier

【 摘 要 】

Polymer nanocapsules assembled on cationic liposomes have been built through the layer-by-layer (LbL) technique. Chitosan and alginate, two biocompatible polyelectrolytes, were used to cover the template, where the Rhodamine B was previously loaded. The multishell formed with the alternate deposition of the polyelectrolytes, according to the principles of the LbL assembly, was supposed to change the permeability of the capsule wall. The thickness of the multishell was seen increasing with the number of layers deposited through the observations with the Transmission Electron Microscope. The permeability of the capsules was studied through Rhodamine B release assays. Nanocapsules with seven layers of polyelectrolytes released the dye slowly compared to the capsules with three or five layers. The Ritger-Peppas model was applied to investigate the release mechanisms and a non-Fickian transport behavior was detected regardless of the number of layers. Values of diffusion coefficients of Rhodamine B through the capsule wall were also calculated. (C) 2014 Elsevier Inc. All rights reserved.

【 授权许可】

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