Interactions of NIPAM nanogels with model lipid multi-bilayers: A neutron reflectivity study

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:536

Article

Sun, Huihui¹  Zielinska, Katarzyna¹  Resmini, Marina¹  Zarbakhsh, Ali¹ 

[1] Queen Mary Univ London, Dept Chem, Joseph Priestley Bldg,Mile End Rd, London E1 4NS, England

关键词: NIPAM nanogel;    Lipid multi-bilayers;    Interaction;    Neutron reflectivity;    Dermal drug delivery;   

DOI  :  10.1016/j.jcis.2018.10.086

来源: Elsevier

【 摘 要 】

In dermal drug delivery, the influence of the chemical structure of the carriers on their penetration mechanisms is not yet fully understood. This is a key requirement in order to design highly efficient delivery systems. In this study, neutron reflectivity is used to provide insights into the interactions between thermoresponsive N-isopropylacrylamide based nanogels, cross-linked with 10%, 20% and 30% N,N'methylenebisacrylamide, and skin lipid multi-bilayers models. Ceramide lipid multi-bilayers and ceramideicholesterolibehenic acid mixed lipid multi-bilayers were used for this work. The results indicated that in both multi-bilayers the lipids were depleted by the nanogels mainly through hydrophobic interactions. The ability of nanogels to associate with skin lipids to form water-dispersible complexes was found to be a function of the percentage cross-linker. An enhanced depletion of lipids was further observed in the presence of benzyl alcohol, a well-known skin penetration enhancer. (C) 2018 Elsevier Inc. All rights reserved.

【 授权许可】

Free