Molecular structure of maltoside surfactants controls micelle formation and rheological behavior

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:581

Article

Larsson, Johan¹  Sanchez-Fernandez, Adrian²  Leung, Anna E.³  Schweins, Ralf⁴  Wu, Baohu⁵  Nylander, Tommy^1,6  Ulvenlund, Stefan^2,7  Wahlgren, Marie^2,7 

[1] Lund Univ, Dept Chem, Phys Chem, Box 124, S-22100 Lund, Sweden

[2] Lund Univ, Food Technol Nutr & Engn, Box 124, S-22100 Lund, Sweden

[3] European Spallat Source, Box 176, S-22100 Lund, Sweden

[4] Inst Laue Langevin, DS LSS, 71 Ave Martyrs, F-38000 Grenoble, France

[5] Forschungszentrum Julich, Heinz Maier Leibnitz Zentrum MLZ, Julich Ctr Neutron Sci JCNS, Lichtenbergstr 1, D-85748 Garching, Germany

[6] Lund Univ, NanoLund, Lund, Sweden

[7] Enza Biotech AB, Scheelevagen 22, S-22363 Lund, Sweden

关键词: Worm-like micelle;    Viscoelastic;    Sugar-based surfactant;    Alkylglycoside;    Rheology;    Small-angle neutron scattering;   

DOI  :  10.1016/j.jcis.2020.08.116

来源: Elsevier

【 摘 要 】

Hypothesis: The anomeric configuration (alpha or beta) of n-hexadecyl-D-maltopyranoside (C(16)G(2)) has been shown to affect the morphology of the micelle, from elongated for alpha-C(16)G(2) to worm-like micelles for beta-C(16)G(2). The entanglement of worm-like micelles often leads to strong modifications of the rheological behavior of the system and, as such, the anomeric configuration of C(16)G(2) could also provide the possibility of controlling this. Furthermore, mixing these surfactants are hypothesized to result in mixed micelles allowing to finely tune the rheology of a system containing these sustainable surfactants. Experiments: The rheology of alpha- and beta-C(16)G(2), and mixtures of those, was determined by rotational and oscillatory rheology at different temperatures and surfactant concentrations. Micelle structure and composition for these systems were characterized using contrast variation small-angle neutron scattering and small-angle X-ray scattering. The results from these were connected in order to elaborate a molecular understanding of the rheological response of the system. Findings: The self-assembly of these surfactants have been found to result in different rheological properties. beta-C(16)G(2) show a high viscosity with a non-Newtonian viscoelastic behavior, which was linked to the formation of worm-like micelles. In contrast, alpha-C(16)G(2) self-assembled into short cylindrical micelles, resulting in a Newtonian fluid with low viscosity. Furthermore, mixtures of these two surfactants lead to systems with intermediate rheological properties as a result of the formation of micelles with intermediate morphology to those of the pure anomers. These results also show that the rheological properties of the system can be tuned to change the micelle morphology, which in turn depends on the anomeric configuration of the surfactant. Also, surfactant concentration, temperature of the system, and micelle composition for surfactant mixtures provide control over the rheological properties of the system in a wide temperature range. Therefore, these results open new possibilities in the development of sustainable excipients for formulation technology, where the characteristics of the system can be easily tailored through geometric variations in the monomer structure whilst maintaining the chemical composition of the system. (C) 2020 The Author(s). Published by Elsevier Inc.

【 授权许可】

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