Development of Worm-like Polymeric Drug Carriers with Multiple Ligands for Targeting Heterogeneous Breast Cancer Cells

Bulletin of the Korean chemical society

Bo Reum Lee¹  Young Taik Oh¹  A Hyeong Lee¹  Kyung Taek Oh¹  Don Haeng Lee¹  Eun Seong Lee¹  Hye Jung Baik¹ 

关键词: Worm-like micelle;    Multiple ligands;    Tumor targeting;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

In this study, wormorm-like polymeric micelles were construted from poly(L-lactic acid)-b-poly(ethyelen glycol) (PLLA-b-PEG) block copolymers via worm-like (or cylindrical) self- assembly that consisted of a relatively long PLLA block (Mn 7K Daltons) at the core and a relatively short PEG block (Mn 2K Daltons) as the shell. Several cancer-targeting moieties (such as folate, cobalamin, and cyclic arginine-glycine-aspartic (RGD) peptide) were chemically coupled with the succinylated or maleimided PEG block of PLLA-b-PEG to act as a cancer cell-specific targeting ligand for breast cancer. The worm-like micelles with muplite cancer cell-specific ligands proved to be successful in recognizing different breast cancer cells at once. This has the potential to aid in cancer-specific drug delivery and to be used as an effective treatment for breast cancer.

【 授权许可】

Unknown