Synthesis, functionalization and properties of uniform europium-doped sodium lanthanum tungstate and molybdate (NaLa(XO4)2, X = Mo,W) probes for luminescent and X-ray computed tomography bioimaging

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:554

Article

Laguna, Mariano¹  Nunez, Nuria O.¹  Becerro, Ana, I¹  Lozano, Gabriel¹  Moros, Maria^2,3  de la Fuente, Jesus M.^2,3  Corral, Ariadna⁴  Balcerzyk, Marcin⁴  Ocana, Manuel¹ 

[1] CSIC US, Inst Ciencia Mat Sevilla, Amer Vespucio 49, Seville, Spain

[2] CSIC UniZar, Inst Ciencia Mat Aragon, Edificio I D,Mariano Esquillor S-N, Zaragoza 50018, Spain

[3] CIBER BBN, Edificio I D,Mariano Esquillor S-N, Zaragoza 50018, Spain

[4] Univ Seville, CNA, Junta Andalucia, CSIC, C Thomas Alva Edison 7, Seville 41092, Spain

关键词: Nanoparticles;    NaLa(WO4)(2);    NaLa(MoO4)(2);    Europium;    Functionalization;    Luminescence;    X-ray computed tomography;   

DOI  :  10.1016/j.jcis.2019.07.031

来源: Elsevier

【 摘 要 】

A one-pot simple procedure for the synthesis of uniform, ellipsoidal Eu3+-doped sodium lanthanum tungstate and molybdate (NaLa(XO4)(2), X = W, Mo) nanophosphors, functionalized with carboxylate groups, is described. The method is based on a homogeneous precipitation process at 120 degrees C from appropriate Na+ Ln(3+) and tungstate or molybdate precursors dissolved in ethylene glycol/water mixtures containing poly acrylic acid. A comparative study of the luminescent properties of both luminescent materials as a function of the Eu3+ doping level has been performed to find the optimum nanophosphor, whose efficiency as X-ray computed tomography contrast agent is also evaluated and compared with that of a commercial probe. Finally, the cell viability and colloidal stability in physiological pH medium of the optimum samples have also been studied to assess their suitability for biomedical applications. (C) 2019 Elsevier Inc. All rights reserved.

【 授权许可】

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