Outcome of renal transplantation with and without intra-operative diuretics

INTERNATIONAL JOURNAL OF SURGERY

卷:9

Article

Hanif, F.¹  Macrae, A. N.¹  Littlejohn, M. G.¹  Clancy, M. J.¹  Murio, E.¹ 

[1] Univ Glasgow, Western Infirm, Transplant Unit, Glasgow G11 6NT, Lanark, Scotland

关键词: Diuretics;    Kidney transplantation;    Acute tubular necrosis;   

DOI  :  10.1016/j.ijsu.2011.04.010

来源: Elsevier

【 摘 要 】

Aims: This paper presents an e-survey of current clinical practice of use of intra-operative diuretics during renal transplantation in the United Kingdom and a study to compare outcome of renal transplants carried out with or without intra-operative diuretics in our centre. Methods: An e-mail questionnaire to renal transplant surgeons exploring their practice of renal transplantation with or without intra-operative diuretics, the type of a diuretic/s if used and the relevant doses. An observational study comparing the outcome of renal transplant recipients, group no-diuretics (GND, n = 80) carried out from 2004 to 2008 versus group diuretics (GD n = 69) renal transplant recipients who received intra-operative diuretics over a one year period is presented. Outcome measures were incidence of delayed graft function and a comparison of graft survival in both groups. Results: Forty surgeons answered from 18 transplant centres with a response rate of 67%. 13 surgeons do not use diuretics. Mannitol is used by 10/40, Furosemide 6/40 and 11 surgeons use a combination of both. In comparative study there was no significant overall difference in one year graft survival of GD versus GND (N = 65/69, 94% and 75/80, 94% respectively, p = 0.08) and the incidence of delayed graft function was also comparable (16/69, 23% and 21/80, 26% respectively, p = 0.07). The donor characteristics in both groups were comparable. Conclusion: The study showed variation in clinical practice on the use of intra-operative diuretics in renal transplantation and it did not demonstrate that the use of diuretics can improve renal graft survival. (C) 2011 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

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