Remote ischaemic preconditioning as a method for perioperative cardioprotection: Concepts, applications and future directions

INTERNATIONAL JOURNAL OF SURGERY

卷:12

Review

Healy, Donagh A.¹  Moloney, Mary Clarke¹  McHugh, Seamus M.¹  Grace, Pierce A.¹  Walsh, Stewart R.¹ 

[1] Univ Limerick, Dept Surg, Limerick, Ireland

关键词: Remote ischaemic preconditioning;    Ischaemic preconditioning;    Cardioprotection;    Cardiac surgery;    Percutaneous coronary intervention;   

DOI  :  10.1016/j.ijsu.2014.08.352

来源: Elsevier

【 摘 要 】

Remote ischaemic preconditioning (RIPC) is a phenomenon whereby brief episodes of non-lethal ischaemia in one organ or tissue can render a distant organ or tissue resistant to subsequent longer ischaemic insults. It represents an exciting perioperative risk reduction strategy as it allows cardioprotection ( and organ protection in general) from injuries that are caused by multiple mechanisms. Several proof of concept studies show benefits in cardiovascular interventions and in a variety of other procedures. However convincing and consistent evidence of benefits in patient important outcomes is lacking but may emerge with the completion of large scale studies. This article aims to provide a concise review of the origins and concepts of RIPC. It will revisit the biological theories of RIPC and the clinical applications thus far. The article concludes by discussing the current status of multi-centre cardiovascular RIPC research and the future challenges that investigators must overcome. (C) 2014 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free