Animal models for liver disease - A practical approach for translational research

JOURNAL OF HEPATOLOGY

卷:73

Review

Nevzorova, Yulia A.^1,2,3  Boyer-Diaz, Zoe^4,5  Javier Cubero, Francisco^2,6  Gracia-Sancho, Jordi^4,5,7,8 

[1] Univ Complutense Madrid, Dept Genet Physiol & Microbiol, Fac Biol, Madrid, Spain

[2] 12 Octubre Hlth Res Inst Imas12, Madrid, Spain

[3] Univ Hosp RWTH Aachen, Dept Internal Med 3, Aachen, Germany

[4] IDIBAPS Biomed Res Inst, Barcelona Hepat Hemodynam Unit, Liver Vasc Biol Res Grp, Barcelona, Spain

[5] Barcelona Liver Bioserv, Barcelona, Spain

[6] Univ Complutense Madrid, Sch Med, Dept Immunol Ophthalmol & ENT, C Doctor Severo Ochoa 9, Madrid 28040, Spain

[7] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain

[8] Univ Bern, Dept Biomed Res, Hepatol, Bern, Switzerland

关键词: Non-alcoholic fatty liver disease;    NAFLD;    Non-alcoholic steatohepatitis;    NASH;    ALD;    Fibrosis;    Cirrhosis;    Primary liver cancer;   

DOI  :  10.1016/j.jhep.2020.04.011

来源: Elsevier

【 摘 要 】

Animal models are crucial for improving our understanding of human pathogenesis, enabling researchers to identify therapeutic targets and test novel drugs. In the current review, we provide a comprehensive summary of the most widely used experimental models of chronic liver disease, starting from early stages of fatty liver disease (non-alcoholic and alcoholic) to steatohepatitis, advanced cirrhosis and end-stage primary liver cancer. We focus on aspects such as reproducibility and practicality, discussing the advantages and weaknesses of available models for researchers who are planning to perform animal studies in the near future. Additionally, we summarise current and prospective models based on human tissue bioengineering. (c) 2020 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

【 授权许可】

Free