Hepatitis B surface antigen seroclearance: Immune mechanisms, clinical impact, importance for drug development

JOURNAL OF HEPATOLOGY

卷:73

Review

Tout, Issam^1,2  Loureiro, Dimitri^1,2  Mansouri, Abdellah^1,2  Soumelis, Vassili^3,4  Boyer, Nathalie^1,2  Asselah, Tarik^1,2 

[1] Univ Paris Diderot, Sorbonne Paris Cite, INSERM, CRI,UMR 1149, F-75018 Paris, France

[2] Hop Beaujon, AP HP, Dept Hepatol, F-92110 Clichy, France

[3] Hop St Louis, St Louis Res Inst, Paris, France

[4] INSERM, U976, Human Immunol Physiopathol & Immunotherapy, Paris, France

关键词: Chronic HBV infection;    HBsAg seroclearance;    Immune system;    Interferon;    Nucleos(t)ide analogues;    HBV therapy;   

DOI  :  10.1016/j.jhep.2020.04.013

来源: Elsevier

【 摘 要 】

HBsAg seroclearance occurs rarely in the natural history of chronic hepatitis B (CHB) infection and is associated with improved clinical outcomes. Many factors are associated with HBsAg seroconversion, including immune and viral factors. However, the immune mechanisms associated with HBsAg seroclearance are still difficult to elucidate. HBsAg seroclearance is the ideal aim of HBV treatment. Unfortunately, this goal is rarely achieved with current treatments. Understanding the mechanisms of HBsAg loss appears to be important for the development of curative HBV treatments. While studies from animal models give insights into the potential immune mechanisms and interactions occurring between the immune system and HBsAg, they do not recapitulate all features of CHB in humans and are subject to variability due to their complexity. In this article, we review recent studies on these immune factors, focusing on their influence on CHB progression and HBsAg seroconversion. These data provide new insights for the development of therapeutic approaches to partially restore the anti-HBV immune response. Targeting HBsAg will ideally relieve the immunosuppressive effects on the immune system and help to restore anti-HBV immune responses. (c) 2020 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

【 授权许可】

Free