Hepatitis C infection and risk of diabetes: A systematic review and meta-analysis

JOURNAL OF HEPATOLOGY

卷:49

Article

White, Donna L.^1,2,3,4  Ratziu, Vlad^5,6  El-Serag, Hashem B.^1,2,3,4 

[1] Michael E DeBakey VA Med Ctr, Baylor Coll Med, Sect Gastroenterol & Hepatol, Houston, TX 77030 USA

[2] Michael E DeBakey VA Med Ctr, Baylor Coll Med, Sect Hlth Serv Res, Houston, TX 77030 USA

[3] Michael E DeBakey VA Med Ctr, Gastroenterol Sect, Houston, TX 77030 USA

[4] Michael E DeBakey VA Med Ctr, Houston Ctr Qual Care & Utilizat Studies, Houston, TX 77030 USA

[5] Univ Paris 06, Paris, France

[6] Grp Hosp Pitie Salpetriere, AP HP, Serv Hepatogastroenterol, F-75634 Paris, France

关键词: Hepatitis C;    Diabetes mellitus;    Type 2;    Meta-analysis;    Review;    Systematic;    Liver diseases;    Hepatitis B;   

DOI  :  10.1016/j.jhep.2008.08.006

来源: Elsevier

【 摘 要 】

Background/Aims: Several studies found hepatitis C (HCV) increases risk of Type II diabetes mellitus (DM). However, others found no or only sub-group specific excess risk. We performed meta-analyses to examine whether HCV infection does increase DM risk in comparison to the general population and in other sub-groups with increased liver disease rates including with hepatitis B (HBV). Methods: We followed standard guidelines for performance of meta-analyses. Two independent investigators identified eligible studies through structured keyword searches in relevant databases including PubMed. Results: We identified 34 eligible studies. Pooled estimators indicated significant DM risk in HCV-infected cases in comparison to non-infected controls in both retrospective (ORadjusted = 1.68, 95% CI 1.15-2.20) and prospective studies (HRadjusted = 1.67, 95% CI 1.28-2.06). Excess risk was also observed in comparison to HBV-infected controls (ORadjusted = 1.80, 95% CI 1.20-1.40) with suggestive excess observed in HCV+/HIV+ cases in comparison to HIV+controls (ORunadjusted = 1.82, 95% CI 1.27-2.38). Conclusions: Our finding of excess DM risk with HCV infection in comparison to non-infected controls is strengthened by consistency of results from both prospective and retrospective studies. The excess risk observed in comparison to HBV-infected controls suggests a potential direct viral role in promoting DM risk, but this needs to be further examined. Published by Elsevier B.V. on behalf of the European Association for the Study of the Liver.

【 授权许可】

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