Vinyl chloride and the liver

JOURNAL OF HEPATOLOGY

卷:51

Review

Sherman, Morris

关键词: Vinyl chloride;    Hepatocellular carcinoma;    Angiosarcoma;   

DOI  :  10.1016/j.jhep.2009.09.012

来源: Elsevier

【 摘 要 】

Vinyl chloride monomer is a known cause of angiosarcoma of the liver. It also has other toxic effects on the liver, and it has recently been suggested that exposure to vinyl chloride also causes hepatocellular carcinoma. However, the data on which this conclusion is based is incomplete. There is inadequate ascertainment of unequivocal diagnoses. In the largest studies lack of data meant that confounding diseases such as viral hepatitis or alcoholic liver disease could not be assessed. At best, the increase in risk is minimal, based on more than 22,000 exposed workers and more than 640,000 person years of observation. However, based on the available data the hypothesis that vinyl chloride causes or contributes to the development of hepatocellular carcinoma remains unproven. (C) 2009 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

【 授权许可】

Free