Current knowledge and management of portal vein thrombosis in cirrhosis

JOURNAL OF HEPATOLOGY

卷:75

Review

Senzolo, Marco¹  Garcia-Tsao, Guadalupe^2,3  Garcia-Pagan, Juan Carlos^4,5,6 

[1] Padua Univ Hosp, Multivisceral Transplant Unit Gastroenterol, Dept Surg Oncol & Gastroenterol, Via Giustninani 2, I-35128 Padua, Italy

[2] VA Connecticut Healthcare Syst, Sect Digest Dis, West Haven, CT USA

[3] Yale Univ, Sch Med, Sect Digest Dis, New Haven, CT 06511 USA

[4] Hosp Clin Barcelona, Liver Unit, Barcelona Hepat Hemodynam Lab, Barcelona, Spain

[5] Univ Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain

[6] CIBEREHD Ctr Invest Biomed Red Enfermedades Hepat, San Sebastian, Spain

关键词: Cirrhosis;    Coagulopathy;    Portal hypertension;    Portal vein thrombosis;    TIPS;    Transplant;   

DOI  :  10.1016/j.jhep.2021.04.029

来源: Elsevier

【 摘 要 】

Portal vein thrombosis (PVT) is an increasingly recognised complication of cirrhosis whose incidence increases in parallel with the severity of cirrhosis. Several risk factors have been associated with the occurrence and progression of PVT. Although the negative effect of complete PVT on the surgical outcome of liver transplant recipients is clear, its impact on cirrhosis progression remains uncertain. Treatment options include anticoagulants and interventional thrombolytic therapies, which are chosen almost on a case-by-case basis depending on the characteristics of the patient and the thrombus. In this manuscript, we review current knowledge regarding the epidemiology, risk factors, diagnosis and classification, natural history, clinical consequences and treatment of non-neoplastic PVT in cirrhosis. (C) 2021 Published by Elsevier B.V. on behalf of European Association for the Study of the Liver.

【 授权许可】

Free