Comparison of the chemical composition of aerosols from heated tobacco products, electronic cigarettes and tobacco cigarettes and their toxic impacts on the human bronchial epithelial BEAS-2B cells

JOURNAL OF HAZARDOUS MATERIALS

卷:401

Article

Dusautoir, Romain¹  Zarcone, Gianni¹  Verriele, Marie²  Garcon, Guillaume¹  Fronval, Isabelle²  Beauval, Nicolas¹  Allorge, Delphine¹  Riffault, Veronique²  Locoge, Nadine²  Lo-Guidice, Jean-Marc¹  Antherieu, Sebastien¹ 

[1] Univ Lille, CHU Lille, IMPECS IMPact Environm Chim Sante Humaine, Inst Pasteur Lille,ULR 4483, F-59000 Lille, France

[2] Univ Lille, IMT Lille Douai, SAGE, F-59000 Lille, France

关键词: Heat-not-burn tobacco;    e-Cigarette;    Lung;    PAHs;    Carbonyls;    Toxicity;   

DOI  :  10.1016/j.jhazmat.2020.123417

来源: Elsevier

【 摘 要 】

The electronic cigarettes (e-cigs) and more recently the heated tobacco products (HTP) provide alternatives for smokers as they are generally perceived to be less harmful than conventional cigarettes. However, it is crucial to compare the health risks of these different emergent devices, in order to determine which product should be preferred to substitute cigarette. The present study aimed to compare the composition of emissions from HTP, e-cigs and conventional cigarettes, regarding selected harmful or potentially harmful compounds, and their toxic impacts on the human bronchial epithelial BEAS-2B cells. The HTP emitted less polycyclic aromatic hydrocarbons and carbonyls than the conventional cigarette. However, amounts of these compounds in HTP aerosols were still higher than in e-cig vapours. Concordantly, HTP aerosol showed reduced cytotoxicity compared to cigarette smoke but higher than e-cig vapours. HTP and e-cig had the potential to increase oxidative stress and inflammatory response, in a manner similar to that of cigarette smoke, but after more intensive exposures. In addition, increasing e-cig power impacted levels of certain toxic compounds and related oxidative stress. This study provides important data necessary for risk assessment by demonstrating that HTP might be less harmful than tobacco cigarette but considerably more harmful than e-cig.

【 授权许可】

Free