Oxidative degradation of endotoxin by advanced oxidation process (O3/H2O2 & UV/H2O2)

JOURNAL OF HAZARDOUS MATERIALS

卷:279

Article

Oh, Byung-Taek¹  Seo, Young-Suk¹  Sudhakar, Dega¹  Choe, Ji-Hyun¹  Lee, Sang-Myeong¹  Park, Youn-Jong²  Cho, Min¹ 

[1] Chonbuk Natl Univ, Coll Environm & Bioresource Sci, Adv Inst Environm & Biosci, Div Biotechnol, Iksan 570752, South Korea

[2] SK E&C, Business Dev Team, Seoul 100130, South Korea

关键词: Advanced oxidation process;    O-3/H2O2;    UV/H2O2;    Endotoxin;    Hydroxyl radical;    TNF-alpha;    Inflammation activity;   

DOI  :  10.1016/j.jhazmat.2014.06.065

来源: Elsevier

【 摘 要 】

The presence of endotoxin in water environments may pose a serious public health hazard. We investigated the effectiveness of advanced oxidative processes (AOP: O-3/H2O2 and UV/H2O2) in the oxidative degradation of endotoxin. In addition, we measured the release of endotoxin from Escherichia coli following typical disinfection methods, such as chlorine, ozone alone and UV, and compared it with the use of AOPs. Finally, we tested the AOP-treated samples in their ability to induce tumor necrosis factor alpha (TNF-alpha) in mouse peritoneal macrophages. The production of hydroxyl radical in AOPs showed superior ability to degrade endotoxin in buffered solution, as well as water samples from Korean water treatment facilities, with the ozone/H2O2 being more efficient compared to UV/H2O2. In addition, the AOPs proved effective not only in eliminating E. coli in the samples, but also in endotoxin degradation, while the standard disinfection methods lead to the release of endotoxin following the bacteria destruction. Furthermore, in the experiments with macrophages, the AOPs-deactivated endotoxin lead to the smallest induction of TNF-a, which shows the loss of inflammation activity, compared to ozone treatment alone. In conclusion, these results suggest that AOPs offer an effective and mild method for endotoxin degradation in the water systems. (C) 2014 Elsevier B.V. All rights reserved.

【 授权许可】

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