Computational modeling of cardiac hemodynamics: Current status and future outlook

JOURNAL OF COMPUTATIONAL PHYSICS

卷:305

Article

Mittal, Rajat¹  Seo, Jung Hee¹  Vedula, Vijay¹  Choi, Young J.¹  Liu, Hang²  Huang, H. Howie²  Jain, Saurabh³  Younes, Laurent³  Abraham, Theodore⁴  George, Richard T.⁴ 

[1] Johns Hopkins Univ, Mech Engn, Baltimore, MD 21218 USA

[2] George Washington Univ, Elect & Comp Engn, Washington, DC 20052 USA

[3] Johns Hopkins Univ, Appl Math & Stat, Baltimore, MD 21218 USA

[4] Johns Hopkins Univ, Div Cardiol, Baltimore, MD 21218 USA

关键词: Hemodynamics;    Computational fluid dynamics;    Cardiac physics;    Blood flow;    Cardiovascular disease;    Heart disease;    Cardiac surgery;    Left ventricular thrombosis;    Heart murmurs;    Cardiac auscultation;    Image segmentation;    Immersed boundary methods;   

DOI  :  10.1016/j.jcp.2015.11.022

来源: Elsevier

【 摘 要 】

The proliferation of four-dimensional imaging technologies, increasing computational speeds, improved simulation algorithms, and the widespread availability of powerful computing platforms is enabling simulations of cardiac hemodynamics with unprecedented speed and fidelity. Since cardiovascular disease is intimately linked to cardiovascular hemodynamics, accurate assessment of the patient's hemodynamic state is critical for the diagnosis and treatment of heart disease. Unfortunately, while a variety of invasive and non-invasive approaches for measuring cardiac hemodynamics are in widespread use, they still only provide an incomplete picture of the hemodynamic state of a patient. In this context, computational modeling of cardiac hemodynamics presents as a powerful noninvasive modality that can fill this information gap, and significantly impact the diagnosis as well as the treatment of cardiac disease. This article reviews the current status of this field as well as the emerging trends and challenges in cardiovascular health, computing, modeling and simulation and that are expected to play a key role in its future development. Some recent advances in modeling and simulations of cardiac flow are described by using examples from our own work as well as the research of other groups. (C) 2015 Elsevier Inc. All rights reserved.

【 授权许可】

Free