Telomeric Chromatin and TERRA

JOURNAL OF MOLECULAR BIOLOGY

卷:432

Review

Barral, Amandine^1,2  Dejardin, Jerome^1,2 

[1] CNRS, UMR 9002, Inst Human Genet, 141 Rue Cardonille, F-34000 Montpellier, France

[2] Univ Montpellier, 141 Rue Cardonille, F-34000 Montpellier, France

关键词: telomere;    lncRNA;    TERRA;    chromatin;    heterochromatin;   

DOI  :  10.1016/j.jmb.2020.03.003

来源: Elsevier

【 摘 要 】

Chromatin function in telomeres is poorly understood, but it is generally viewed as repressive. Yet, telomeric DNA sequences are transcribed into long non-coding RNAs named TElomere Repeat-containing RNA (TERRA). As TERRA molecules mostly localize at telomeres, major research efforts have been made to understand their functions, and how TERRA transcription is regulated and affects telomere structure. This review describes the current state of knowledge about the nature of chromatin at telomeres, its functions, and the relation between chromatin structure and TERRA. (C) 2020 Elsevier Ltd. All rights reserved.

【 授权许可】

Free