Epigenetic Drivers of Cancer

JOURNAL OF MOLECULAR BIOLOGY

卷:433

Review

Butera, Alessio¹  Melino, Gerry¹  Amelio, Ivano^1,2 

[1] Univ Roma Tor Vergata, TOR Ctr Excellence, Rome, Italy

[2] Univ Nottingham, Sch Life Sci, Nottingham, England

关键词: cancer epigenetics;    transcriptional rewiring;    gene-environment interaction;    cancer;    cancer genetics;   

DOI  :  10.1016/j.jmb.2021.167094

来源: Elsevier

【 摘 要 】

Genetics is at the basis of cancer initiation and evolution, but emerging evidence indicates that mutations are not sufficient to produce cancer, indicating a role for epigenetic contributions to the different stages of tumorigenesis. While the genetic tracks of cancer have been widely investigated, the epigenetic drivers remain a vague definition. Gene-environment interactions can produce gene-regulatory programs that dictate pathogenesis; this implies a reciprocal relationship where environmental factors contribute to genetic mechanisms of tumorigenesis (i.e. mutagenesis) and genetic factors influence the cellular response to extrinsic stress. In this review article, we attempt to summarise the most remarkable findings demonstrating a contribution of epigenetic factors as proper drivers of tumorigenesis. We also try to pose attention on the relevance of epigenetic mechanisms as downstream consequences of genes versus environment interaction. (C) 2021 The Authors. Published by Elsevier Ltd.

【 授权许可】

Free