New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer

Cancer Communications

Kui‐Sheng Chen¹  Miao‐Miao Sun¹  Yan He²  Long Liao³  Zi‐Ting Yao³  Yan‐Ming Yang³  Bin Li³ 

[1] Department of Pathology Henan Key Laboratory of Tumor Pathology the First Affiliated Hospital of Zhengzhou University Zhengzhou Henan 450001 P. R. China;Ministry of Education Key Laboratory of Tumor Molecular Biology and Guangdong Provincial Key Laboratory of Bioengineering Medicine National Engineering Research Center of Genetic Medicine Institute of Biomedicine College of Life Science and Technology Jinan University Guangzhou Guangdong 510632 P. R. China;Ministry of Education Key Laboratory of Tumor Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes Institute of Life and Health Engineering Jinan University Guangzhou Guangdong 510632 P. R. China;

关键词: cancer epigenetics;    cancer;    interaction network;    lncRNA‐RBP;    long non‐coding RNA;    RNA‐binding protein;   

DOI  :  10.1002/cac2.12254

来源: DOAJ

【 摘 要 】

Abstract With the development of proteomics and epigenetics, a large number of RNA‐binding proteins (RBPs) have been discovered in recent years, and the interaction between long non‐coding RNAs (lncRNAs) and RBPs has also received increasing attention. It is extremely important to conduct in‐depth research on the lncRNA‐RBP interaction network, especially in the context of its role in the occurrence and development of cancer. Increasing evidence has demonstrated that lncRNA‐RBP interactions play a vital role in cancer progression; therefore, targeting these interactions could provide new insights for cancer drug discovery. In this review, we discussed how lncRNAs can interact with RBPs to regulate their localization, modification, stability, and activity and discussed the effects of RBPs on the stability, transport, transcription, and localization of lncRNAs. Moreover, we explored the regulation and influence of these interactions on lncRNAs, RBPs, and downstream pathways that are related to cancer development, such as N6‐methyladenosine (m6A) modification of lncRNAs. In addition, we discussed how the lncRNA‐RBP interaction network regulates cancer cell phenotypes, such as proliferation, apoptosis, metastasis, drug resistance, immunity, tumor environment, and metabolism. Furthermore, we summarized the therapeutic strategies that target the lncRNA‐RBP interaction network. Although these treatments are still in the experimental stage and various theories and processes are still being studied, we believe that these strategies may provide new ideas for cancer treatment.

【 授权许可】

Unknown