Structural Pharmacology of TRP Channels

JOURNAL OF MOLECULAR BIOLOGY

卷:433

Review

Zhao, Yaxian¹  McVeigh, Bridget M.¹  Moiseenkova-Bell, Vera Y.¹ 

[1] Univ Penn, Perelman Sch Med, Dept Syst Pharmacol & Translat Therapeut, Philadelphia, PA 19104 USA

关键词: ion channels;    TRP channel;    structural biology;    cryo-EM;   

DOI  :  10.1016/j.jmb.2021.166914

来源: Elsevier

【 摘 要 】

Transient receptor potential (TRP) ion channels are a super-family of ion channels that mediate transmembrane cation flux with polymodal activation, ranging from chemical to physical stimuli. Furthermore, due to their ubiquitous expression and role in human diseases, they serve as potential pharmacological targets. Advances in cryo-EM TRP channel structural biology has revealed general, as well as diverse, architectural elements and regulatory sites among TRP channel subfamilies. Here, we review the endogenous and pharmacological ligand-binding sites of TRP channels and their regulatory mechanisms. (C) 2021 Elsevier Ltd. All rights reserved.

【 授权许可】

Free