Structural and functional diversity calls for a new classification of ABC transporters

FEBS Letters

article

Christoph Thomas¹  Stephen G. Aller²  Konstantinos Beis³  Elisabeth P. Carpenter⁵  Geoffrey Chang⁶  Lei Chen⁷  Elie Dassa⁹  Michael Dean^1,10  Franck Duong Van Hoa^1,11  Damian Ekiert^1,12  Robert Ford^1,13  Rachelle Gaudet^1,14  Xin Gong^1,15  I. Barry Holland^1,16  Yihua Huang^1,17  Daniel K. Kahne^1,18  Hiroaki Kato^1,19  Vassilis Koronakis^2,20  Christopher M. Koth^2,21  Youngsook Lee^2,22  Oded Lewinson^2,23  Roland Lill^2,24  Enrico Martinoia^2,25  Satoshi Murakami^2,27  Heather W. Pinkett^2,28  Bert Poolman^2,29  Daniel Rosenbaum^3,30  Balazs Sarkadi^3,31  Lutz Schmitt^3,32  Erwin Schneider^3,33  Yigong Shi^3,34  Show-Ling Shyng^3,35  Dirk J. Slotboom^2,29  Emad Tajkhorshid^3,36  D. Peter Tieleman^3,37  Kazumitsu Ueda^1,19  András Váradi^3,31  Po-Chao Wen^3,36  Nieng Yan^3,38  Peng Zhang^3,39  Hongjin Zheng^4,40  Jochen Zimmer^4,41  Robert Tampé¹ 

[1] Institute of Biochemistry, Goethe University Frankfurt;Department of Pharmacology and Toxicology, University of Alabama at Birmingham;Department of Life Sciences, Imperial College London;Rutherford Appleton Laboratory, Research Complex at Harwell;University of Oxford;Skaggs School of Pharmacy and Pharmaceutical Sciences and Department of Pharmacology, School of Medicine, University of California;State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University;Peking-Tsinghua Center for Life Sciences, Peking University;Institut Pasteur;Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH;Department of Biochemistry and Molecular Biology, Faculty of Medicine, Life Sciences Institute, University of British Columbia;Department of Cell Biology and Department of Microbiology, New York University School of Medicine;Faculty of Biology, Medicine and Health, The University of Manchester;Department of Molecular and Cellular Biology, Harvard University;Department of Biology, Southern University of Science and Technology;Institute for Integrative Biology of the Cell (I2BC), Université Paris-Sud;National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences;Department of Chemistry and Chemical Biology, Harvard University;Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University;Department of Pathology, University of Cambridge;Structural Biology, Genentech Inc;Division of Integrative Bioscience and Biotechnology, POSTECHgy;Department of Biochemistry, The Bruce and Ruth Rappaport Faculty of Medicine, The Technion-Israel Institute of Technology;Institut für Zytobiologie, Philipps-Universität Marburg;Department of Plant and Microbial Biology, University Zurich;International Research Centre for Environmental Membrane Biology, Foshan University;Department of Life Science, Tokyo Institute of Technology;Department of Molecular Biosciences, Northwestern University;Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen;Department of Biophysics, University of Texas Southwestern Medical Center;Institute of Enzymology, Research Center for Natural Sciences (RCNS);Institute of Biochemistry, Heinrich Heine University Düsseldorf;Department of Biology/Microbial Physiology, Humboldt-University of Berlin;Institute of Biology, Westlake Institute for Advanced Study, School of Life Sciences, Westlake University;Department of Chemical Physiology and Biochemistry, Oregon Health & Science University;Department of Biochemistry, Center for Biophysics and Quantitative Biology, NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign;Department of Biological Sciences and Centre for Molecular Simulation, University of Calgary;Department of Molecular Biology, Princeton University;National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences;Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus;University of Virginia School of Medicine

关键词: ABC transporters;    ATPases;    cryo-EM;    membrane proteins;    molecular machines;    phylogeny;    primary active transporters;    sequence alignment;    structural biology;    X-ray crystallography;   

DOI  :  10.1002/1873-3468.13935

来源: John Wiley & Sons Ltd.

【 摘 要 】

Members of the ATP-binding cassette (ABC) transporter superfamily translocate a broad spectrum of chemically diverse substrates. While their eponymous ATP-binding cassette in the nucleotide-binding domains (NBDs) is highly conserved, their transmembrane domains (TMDs) forming the translocation pathway exhibit distinct folds and topologies, suggesting that during evolution the ancient motor domains were combined with different transmembrane mechanical systems to orchestrate a variety of cellular processes. In recent years, it has become increasingly evident that the distinct TMD folds are best suited to categorize the multitude of ABC transporters. We therefore propose a new ABC transporter classification that is based on structural homology in the TMDs.

【 授权许可】

Unknown