Physics and Biology (of Chromosomes)

JOURNAL OF MOLECULAR BIOLOGY

卷:432

Article

Marko, John F.^1,2,3 

[1] Northwestern Univ, Dept Phys & Astron, Evanston, IL 60208 USA

[2] Northwestern Univ, Dept Mol Biosci, Evanston, IL 60208 USA

[3] Sorbonne Univ, CNRS, LPTMC, F-75005 Paris, France

关键词: chromosomes;    chromatin;    quantitative biology;    phase separation;    polymer biophysics;   

DOI  :  10.1016/j.jmb.2019.11.022

来源: Elsevier

【 摘 要 】

Advances in molecular biology, optics, genetics, and bioinformatics have opened the door to mapping, in molecular detail, processes inside living cells. With the ability to observe the individual moving parts of cellular machinery, concepts formerly confined to physics are entering mainstream biology. This article discusses a few ideas of this sort related to chromosome biology, to illustrate what kinds of insights physics might yet bring to our understanding of living systems. (C) 2019 Elsevier Ltd. All rights reserved.

【 授权许可】

Free