Chromatin Structure with Respect to Histone Signature Changes during Cell Differentiation

Cell Structure and Function

Andrea Harniლrová Horáková¹  Eva Bártová¹  Stanislav Kozubek¹ 

[1] Institute of Biophysics Academy of Sciences of the Czech Republic

关键词: chromatin;    gene expression;    differentiation;    enterocytes;    chromosomes;   

DOI  :  10.1247/csf.09021

学科分类：分子生物学，细胞生物学和基因

来源: Japan Society for Cell Biology

【 摘 要 】

References(141)Cited-By(1)Here, we would like to point out important milestones in the study of nuclear radial positioning and gene expression during differentiation processes. In addition, changes in the histone signature that significantly precede various differentiation pathways are reviewed. We address the regulatory functions of chromatin structure and histone epigenetic marks that give rise to gene expression patterns that are specific to distinct differentiation pathways. The functional relevance of nuclear architecture and epigenetic traits is preferentially discussed in the context of in vitro induced enterocytic differentiation and pluripotent or differentiated embryonic stem cells. We especially focus on the recapitulation of nuclear events that have been characterized for some genes and proto-oncogenes that are important for development and differentiation.

【 授权许可】

Unknown