MicroRNAs and the Genetic Network in Aging

JOURNAL OF MOLECULAR BIOLOGY

卷:425

Review

Inukai, Sachi¹  Slack, Frank¹ 

[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06511 USA

关键词: lifespan;    insulin signaling;    small noncoding RNAs;    Caenorhabditis elegans;   

DOI  :  10.1016/j.jmb.2013.01.023

来源: Elsevier

【 摘 要 】

MicroRNAs (miRNAs) comprise a class of small RNAs important for the posttranscriptional regulation of numerous biological processes. Their combinatorial mode of function, in which an individual miRNA can target many genes and multiple miRNAs share targets, makes them especially suited for regulating processes and pathways at the network level. In particular, miRNAs have recently been implicated in aging, which is a complex process known to involve multiple pathways. Findings from genome-wide miRNA expression profiling studies highlight three themes in miRNA function during aging: many miRNAs are differentially expressed, many such miRNAs target known aging-associated pathways, and there are global trends in miRNA expression change over time. In addition, several miRNAs have emerged as potentially coordinating multiple pathways during aging. Elucidating the underlying network structure of genes and miRNAs involved in aging processes promises to advance our understanding of not only aging and associated pathogenesis but also how miRNAs can connect disparate pathways. (c) 2013 Elsevier Ltd. All rights reserved.

【 授权许可】

Free