The dynamin‐related protein DRP‐1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity

Aging Cell

Christine C. Yang¹  Diana Chen¹  Siu Sylvia Lee¹ 

[1] Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA

关键词: aging;    Caenorhabditis elegans;    fission protein DRP‐1;    insulin signaling;    mitochondria;   

DOI  :  10.1111/j.1474-9726.2011.00711.x

来源: Wiley

【 摘 要 】

Summary

Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that mitochondrial morphology and IIS cooperate to modulate aging.

【 授权许可】

Unknown   
© 2011 The Authors. Aging Cell © 2011 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland